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2 edition of Drug diffusion across the human erythrocyte membrane. found in the catalog.

Drug diffusion across the human erythrocyte membrane.

Joseph Oswald McHugh

Drug diffusion across the human erythrocyte membrane.

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Published by University of Salford in Salford .
Written in English


Edition Notes

PhD thesis, Chemistry.

SeriesD30175/80
ID Numbers
Open LibraryOL21848231M

-simple diffusion (e.g. gases, H 2 0,, steroids, lipid soluble vitamins, thyroxine). Molecules that have a high lipid solubility can cross the barrier by direct diffusion across the lipid bilayers of the SCT. Steroid hormones and their precursors are of particular significance.


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Drug diffusion across the human erythrocyte membrane. by Joseph Oswald McHugh Download PDF EPUB FB2

The effect is due to the incorporation of a portion of drug substances into the BSA-nanoparticles, which consequently leads to the decrease of the active drug concentrations in the erythrocyte.

Transbilayer diffusion is permeation of small-molecule drugs across the intact bilayer, in any molecular form or species, without interacting with any membrane components besides the lipids. Carrier-mediated transport requires binding of drug molecules to native, membrane-bound carrier macromolecules, which then translocate the drug molecules Cited by: 6.

A summary of results for the erythrocyte membrane is presented in Fig. 43 Clearly there is a significant asymmetry in the distribution of phospholipids across the erythrocyte membrane. The outer leaflet of the erythrocyte membrane contains primarily phosphatidylcholine and sphingomyelin.

Transport and Diffusion across Cell Membranes is a comprehensive treatment of the transport and diffusion of molecules and ions across cell membranes.

Drug diffusion across the human erythrocyte membrane. book book shows that the same kinetic equations (with appropriate modification) can describe all the specialized membrane transport systems: the pores, the carriers, and the two classes of pumps. Assuming the oxygen partition coefficient between the membrane and aqueous phases to bethe diffusion coefficients for oxygen at 37°C are x cm2/sec in dimyristoyl lecithin vesicles, 9.

Kinetics and thermodynamics of chloroquine and hydroxychloroquine transport across the human erythrocyte membrane.

Biochemical Pharmacology41 (1), DOI: /(91)Q. Kleutsch, P. by: Action of Drugs on the Erythrocyte Membrane. Authors; Authors and affiliations B. F., and Duhm, J.,Evidence for anionic cation transport of lithium, sodium and potassium across the human erythrocyte membrane induced by S.

J.,Biological membranes as bilayer couples. A molecular mechanism of drug—erythrocyte interactions Cited by: Erythrocyte Membrane Human Erythrocyte Osmotic Fragility Erythrocyte Ghost Human Erythrocyte Membrane These keywords were added by machine and not by the authors.

This process is experimental and the keywords may be updated as the learning algorithm by: 1. Thermodynamics and membrane processes - Volume 15 Issue 4 - Roger A.

Klein. Diffusion of univalent ions across the lamellae of swollen phospholipids. molec. Determination of equivalent pore radius for human red cells by osmotic pressure by: A biological membrane or biomembrane is an enclosing or separating membrane that acts as a selectively permeable barrier within living ical membranes, in the form of eukaryotic cell membranes, consist of a phospholipid bilayer with embedded, integral and peripheral proteins used in communication and transportation of chemicals and bulk of lipid in a cell membrane provides.

Brain drug delivery (Figure 3C). The abundance of GLUT1 within the human erythrocyte plasma membrane is said to be highest of all transporters. Yet, the abundance of GLUT1 glucose transporter, expressed as transporter molecules per micron of membrane length, is fold higher on the Drug diffusion across the human erythrocyte membrane.

book membrane of the human brain capillary endothelium. The rate that the amino acid tryptophan can passively diffuse across a membrane is about times slower than the molecule, indole (If you don't know the structures of these two molecules, look them up in the book or on the internet).

Occurrence of such events would also imply that the degree of spreading of the RBC membrane skeleton is heterogeneous across the RBC membrane, which could lead to spatial heterogeneities in the force distribution across the membrane, possibly driving RBC membrane curvature and biconcave shape (Mohandas et al., ; Mohandas and Chasis, ).

The function of any given biological membrane is determined largely by the specific set of integral membrane proteins embedded in it, and the peripheral membrane proteins attached to the membrane surface.

The activity of these proteins, in turn, can be modulated by the phospholipid composition of the membrane. The reconstitution of membrane proteins into a model membrane allows investigation Cited by: The intracellular fluid of erythrocytes is a solution of salts, glucose, protein and hemoglobin.

A % NaCl solution is said to be isotonic: when blood cells reside in such a medium, the intracellular and extracellular fluids are in osmotic equilibrium across the cell membrane, and there is no net influx or efflux of water.

A series of positively charged sulfonamides were obtained by reaction of aminobenzolamide [5-(4-aminobenzenesulfonylamino)-1,3,4-thiadiazolesulfonamide] with tri-/tetrasubstituted pyrilium salts possessing alkyl- aryl- or combinations of alkyl and aryl groups at the pyridinium ring.

The new compounds reported here were assayed for the inhibition of four physiologically relevant carbonic Cited by: Tonicity is a measure of the effective osmotic pressure gradient; the water potential of two solutions separated by a semipermeable cell membrane.

In other words, tonicity is the relative concentration of solutes dissolved in solution which determine the direction and extent of is commonly used when describing the response of cells immersed in an external solution.

The cell membrane has gained significant attention as a platform for the development of bio-inspired nanodevices due to its immune-evasive functionalities and copious bio-analogs. This review will examine several uses of cell membranes such as (i) therapeutic delivery carriers with or without substrates (i.e., nanoparticles and artificial polymers) that have enhanced efficiency regarding Cited by: 3.

COVID Resources. Reliable information about the coronavirus (COVID) is available from the World Health Organization (current situation, international travel).Numerous and frequently-updated resource results are available from this ’s WebJunction has pulled together information and resources to assist library staff as they consider how to handle coronavirus.

• The potential difference across the membrane can be built up either directly (inter/ intra cellular electrodes) or indirectly by applying electric field pulse to cell suspension.

• Mechanical rupture of membrane occurs when polarized with mv for the period exceeding 10 µsec resulting in 10 pores/cm with pore size 3 nm. 21 Effects of membrane interaction on drug action and drug distribution are discussed, and numerous examples are given.

This unique reference volume builds on the authors' long experience in the study of drug-membrane interaction. Recommended reading for everyone involved in pharmaceutical research. Baker RF. Entry of ferritin into human red cells during hypotonic haemolysis.

Nature ; – PubMed Crossref Google Scholar. Bangham A, Standish MM, Watkins J. Diffusion of univalent ions across the lamellae of swollen phospholipids. J Mol Biol ; – Crossref PubMed Google Scholar. Banz A, Cremel M, Rembert A Cited by: 5. Red cells are full of unique biological properties such as immune evasion and molecular-specific permeability.

These properties originate from various membrane proteins on the surface of the cell membrane. For this reason, red cell membrane is coated on nanomaterials or sensors to bestow the functionalities of the membrane proteins.

In this chapter, various types of membrane proteins of red Author: Insu Kim, Gyudo Lee, Dae Sung Yoon. A human is, according to the most recent estimates, an assortment of ±×10 13 cells (BNID ), plus a similar complement of allied microbes.

The identities of the human cells are distributed amongst more than different cell types (BNID) which perform a.

We have developed a new approach, to our knowledge, to quantify the equilibrium exchange kinetics of carrier-mediated transmembrane transport of fluorinated substrates.

The method is based on adapted kinetic theory that describes the concentration dependence of the transmembrane exchange rates of two competing, simultaneously transported by: 4. Introduction. Membrane transporters mediate the transport of solutes across cell and organelle membranes.

Transport processes can generate concentration gradients (e.g., active transport process) and membrane potentials (i.e., electrochemical gradient), and they contribute to the regulation of biochemical pathways by maintaining the cellular concentrations of substrates and products (e.g Cited by: The lipid bilayer is very thin compared to its lateral dimensions.

If a typical mammalian cell (diameter ~10 micrometers) were magnified to the size of a watermelon (~1 ft/30 cm), the lipid bilayer making up the plasma membrane would be about as thick as a piece of office paper.

Despite being only a few nanometers thick, the bilayer is composed of several distinct chemical regions across its. Intracellular bacterial pathogens are hard to treat because of the inability of conventional antimicrobial agents belonging to widely used classes, like aminoglycosides and β-lactams, fluoroquinolones, or macrolides to penetrate, accumulate, or be retained in the mammalian cells.

The increasing problem of antibiotic resistance complicates more the treatment of the diseases caused by these by: 3. Next we will derive equations for receptor-mediated diffusion across a membrane - facilitated diffusion. We will deal with the situation when the solute must be transported up a concentration gradient (which requires ATP as an exogenous source of energy), a process called active transport, later in this web book.

Specific Cation Modulation of Anion Transport Across the Human Erythrocyte Membrane. Low PS. Biochem. Biophys. Acta (). Calcium-Anesthetic Interactions in the Erythrocyte Membrane.

Low PS, Roger JA III. Supramol. Structures, Suppl. The Interaction of Adenine Nucleotides with the Red Cell Membrane: A Calorimetric.

"After being frequently urged to write upon this subject, and as often declining to do it, from apprehension of my own inability, I am at length compelled to take up the pen, however unqualified I may still feel myself for the task.

" William Withering, M. ' I have yet to find a description or Price: $ For transport across membranes, these ideas have been codified in the simple equation (for neutral solute) j= – p(c in-c out), where j is the net flux into the cell, c in and c out refer to the concentrations on the inside and outside of the membrane bound region, and p is a material parameter known as the permeability.

The units of p can. Effects of p-chloromercuribenzene sulfonate on water transport across the marsupial erythrocyte membrane. Journal of Comparative Physiology B: Biochemical, Systemic, and Environmental Physiology, (6), The introductory book's transparency indicated that "GLUT-1 facilitates glucose diffusion." Answer either why they selected the words (1) "facilitates," or (2) "diffusion." (1) glucose needs a path across the membrane, (2) but it is not a pump that requires energy.

Use of steady-state Laurdan fluorescence to detect changes in liquid ordered phases in human erythrocyte membranes.

J Membrane Biol. ; (1): Abstract, Publisher, Internal PDF. The respiratory system works in conjunction with the cardiovascular system to provide oxygen to cells within every body system for cellular metabolism.

The respiratory system also removes carbon dioxide. Since CO2 is mainly transported in the plasma as bicarbonate ions, which act as a chemical buffer, the respiratory system also helps maintain. The flux of molecule A (J A) across a membrane of thickness dx, is proportional to the concentration gradient across the membrane, dA/dx., which gives Fick's First Law of Diffusion: J A a dA/dx or J A = - D dA/dx.

where D is the diffusion coefficient (cm 2 /s). The negative sign is necessary since concentration increases in the opposite. Oligosaccharide chains are attached to glycoproteins in secretion, to glycolipids in plasma, and to both on the erythrocyte membrane.

About 70 percent of ABH-I antigens on the membrane are carried on glycoproteins, primarily the anion transporter band 3, but also on the glucose transporter bandthe Rh glycoprotein, and others. The BC Open Textbook project managed by BCcampus has added this OpenStax open textbook to Pressbooks so that editable Pressbooks and WordPress xml files could be provided as part of this book’s record in the BC Open Textbook collection.

This copy of this OpenStax textbook is not a derivative of the original work as no changes have been made to this textbook with the exception of minor. Functions of cell membrane: Latest News, Information, Answers and Websites What is the functions of the cell membrane. Answer: The cell membrane is the boundary that seperates one cell from either its neighboring cells or its liquid environment.

It holds the cellular contents together, determines the shape of the cell and is semi-permeable which means it allows some particles to cross it. As a consequence of these modifications, there is an increase in protein C kinase activity in the RBC membrane, which provokes phosphorylation of membrane proteins, such as protein R, or band-3, and promotes a decrease in the interactions between erythrocyte membrane and cytoskeleton, increasing deformability by: 6.Membrane transporters enable efficient cellular metabolism, aid in nutrient sensing, and have been associated with various diseases, such as obesity and cancer.

Genome-scale metabolic network reconstructions capture genomic, physiological, and biochemical knowledge of a target organism, along with a detailed representation of the cellular metabolite transport by: ISBN: OCLC Number: Description: xv, pages: illustrations (chiefly color) ; 28 cm: Contents: 1 Introduction to Cell Biology The Discovery of Cells 2Microscopy 2Cell Theory Basic Properties of Cells 3Cells are Highly Complex and Organized 3Cells Possess a Genetic Program and the Means to Use It 5Cells Are Capable of Producing More of.